At the beginning of 2015, the first cases in Brazil were reported and the virus caused a serious epidemic resulting in over 200 thousand cases. After 60 years without major outbreaks, ZIKV was responsible for an epidemic in the Yap Islands in 2007 and then in French Polynesia in 2012–2013. ZIKV was first identified in 1947 when scientists discovered the then unknown virus from a febrile rhesus monkey used in yellow fever research in the Zika forest, Uganda. The virus has icosahedral symmetry and its genome consists of a single strand of positive-sense RNA, which is translated into structural (C, prM, E) and non-structural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5) proteins. This epidemic arbovirus is transmitted mainly by the bites of infected mosquitos from the genus Aedes and, possibly, Culex. Zika virus (ZIKV) is a Flavivirus that belongs to the Flaviviridae family. According to the molecular docking compound, 4b was suggested with significant binding affinity for the NS5 RdRp protein target, which was further corroborated by molecular dynamic simulation studies. There were no significant results for the pre-treatment test. After screening with all compounds, 4b was the most active against ZIKV in the post-infection test, obtaining a 50% inhibition concentration (IC 50) of 146.0 µM and SI of 2.3. Most compounds showed low cytotoxicity to epithelial cells, specially the 3b compound. Thus, in this work we evaluate the cytotoxicity and antiviral activities of 14 hybrid compounds formed by 1 H-1,2,3-triazole, naphthoquinone and phthalimide groups. Although it has become endemic in most parts of the tropical world, Zika still does not have a specific treatment. ZIKV has a single strand positive-sense RNA genome that is translated into structural and non-structural (NS) proteins. Zika virus (ZIKV) is a mosquito-borne virus belonging to the Flaviviridae family and is responsible for an exanthematous disease and severe neurological manifestations, such as microcephaly and Guillain-Barré syndrome.
0 kommentar(er)
